Table 2

Concentration of CEP-701 in blood plasma and H rat prostate cancer tissue in animals given two cycles of 10 mg p.o. of CEP-701/kg body weight BID for 5 days/week/cycle

Time after last oral dose, hCEP-701 concentration in
Plasma (nm)H tumor (nm)
1 (n = 3)4.5 ± 2.335.6 ± 6.6
2 (n = 3)49.2 ± 30.026.6 ± 18.6
4 (n = 3)6.8 ± 2.330.2 ± 15.0
8–12 (n = 5)<250.4 ± 39.7