Table 3

Relationship between clinicopathological variables and apoptosis:Ki-67 ratio

nRatio of apoptosis:Ki-67 (Mean ± SD)Krukas-Wallis (Wilcoxon test) PMultiple linear regression − adjusted Pa
MSI
 MSI-H310.04 ± 0.004
 MSI-L290.04 ± 0.004
 MSS400.02 ± 0.003<0.0010.004
Side
 Left510.03 ± 0.003
 Right480.03 ± 0.0030.430.36
TIL
 Negative620.03 ± 0.003
 Positive380.04 ± 0.0040.080.88
Stage
 A140.03 ± 0.005
 B470.03 ± 0.004
 C220.03 ± 0.005
 D150.04 ± 0.0060.770.93
Grade
 Moderate/Well700.03 ± 0.003
 Poorly differentiated300.03 ± 0.0030.260.71
Type
 Adenocarcinoma790.03 ± 0.002
 Mucinous210.04 ± 0.0060.350.91
TP53 b
 Negative410.03 ± 0.004
 Positive380.03 ± 0.0040.720.16
K-ras mutationc
 Negative600.03 ± 0.003
 Positive170.02 ± 0.0030.19
  • a Linear regression model was applied to the squared transformation of Ki-67 percentage that was closer to the normal distribution. Variables included in the model are patient age and sex, MSI, TIL status, stage, tumor site, stage, grade, type, and TP53 LOH.

  • b Analysis is based on results from 19 MSI-H, 22 MSI-L, and 38 MSS cancers.

  • c Analysis is based on results from 19 MSI-H, 20 MSI-L, and 38 MSS cancers.