n | Ratio of apoptosis:Ki-67 (Mean ± SD) | Krukas-Wallis (Wilcoxon test) P | Multiple linear regression − adjusted P^{a} | |
---|---|---|---|---|
MSI | ||||
MSI-H | 31 | 0.04 ± 0.004 | ||
MSI-L | 29 | 0.04 ± 0.004 | ||
MSS | 40 | 0.02 ± 0.003 | <0.001 | 0.004 |
Side | ||||
Left | 51 | 0.03 ± 0.003 | ||
Right | 48 | 0.03 ± 0.003 | 0.43 | 0.36 |
TIL | ||||
Negative | 62 | 0.03 ± 0.003 | ||
Positive | 38 | 0.04 ± 0.004 | 0.08 | 0.88 |
Stage | ||||
A | 14 | 0.03 ± 0.005 | ||
B | 47 | 0.03 ± 0.004 | ||
C | 22 | 0.03 ± 0.005 | ||
D | 15 | 0.04 ± 0.006 | 0.77 | 0.93 |
Grade | ||||
Moderate/Well | 70 | 0.03 ± 0.003 | ||
Poorly differentiated | 30 | 0.03 ± 0.003 | 0.26 | 0.71 |
Type | ||||
Adenocarcinoma | 79 | 0.03 ± 0.002 | ||
Mucinous | 21 | 0.04 ± 0.006 | 0.35 | 0.91 |
TP53 ^{b} | ||||
Negative | 41 | 0.03 ± 0.004 | ||
Positive | 38 | 0.03 ± 0.004 | 0.72 | 0.16 |
K-ras mutation^{c} | ||||
Negative | 60 | 0.03 ± 0.003 | ||
Positive | 17 | 0.02 ± 0.003 | 0.19 |
^{a} Linear regression model was applied to the squared transformation of Ki-67 percentage that was closer to the normal distribution. Variables included in the model are patient age and sex, MSI, TIL status, stage, tumor site, stage, grade, type, and TP53 LOH.
^{b} Analysis is based on results from 19 MSI-H, 22 MSI-L, and 38 MSS cancers.
^{c} Analysis is based on results from 19 MSI-H, 20 MSI-L, and 38 MSS cancers.