Table 5

Summary of studies assessing the relationship between proliferation, apoptosis, and prognosis in sporadic CRCs

Author and yearnTumor stageMSI analysisMultivariant analysisProliferation measurePI as a prognostic indicatorApoptosis measureAI as a prognostic indicatorRef.
Schutte et al., 1987279AllNoYesFlow cytometryYes (stage C)NDaND (51)
Harlow et al., 199169C onlyNoYesFlow cytometryYesNDND (49)
Witzig et al., 1991694B2/CNoYesFlow cytometryYesNDND (50)
Barreton et al., 199695A/BNoYesKi-67 immunoNoTUNELNo (45)
Kyzer et al., 199730B/C/DNoNoKi-67 immunoYes (stage D)NDND (42)
Jansson et al., 1997255AllNoNoKi-67 immunoNoNDND (43)
Sinicrope et al., 1999154A/BNoYesFlow cytometryNoH&E stainNo (44)
  • a ND, not done; TUNEL, terminal deoxynucleotidyl transferase-mediated nick end labeling; immuno, immunohistochemistry.