Table 1

Mutations in the PTEN gene in endometrial carcinomas

CaseNucleotideCodonAlterationChangeStageHistotypea
110636G→TGly to StopIIAAS
2800267Del AStop 275IIBSCC
3895299G→TGlu to StopIIAEM (G2)
4697233C→TArg to StopIVBEM (G2)
5388130C→GArg to GlyIIBAS
952–955318–319Del CTTAStop 319
6952–955318–319Del CTTAStop 319ICEM (G1)
1003335C→TArg to Stop
720268T→CTyr to HisICEM (G2)
388130C→GArg to Gly
8952–955318–319Del CTTAStop 319IIIAEM (G3)
9388130C→GArg to GlyIIICEM (G2)
10867289Del AStop 290IIICEM (G2)
11940314Ins GStop 324IBEM (G1)
12885296Ins AStop 297IIICEM (G2)
13800267Del AStop 275IIICEM (G1)
14952–955318–319Del CTTAStop 319IIICAS
15999333Ins 7bpStop 344ICEM (G1)
16388130C→GArg to GlyIIICEM (G1)
17405–423135–141Del 19bpStop 140IVBEM (G3)
183713A→GLys to GluIIIAEM (G3)
7626A→CThr to Pro
191021341T→GPhe to ValIBEM (G2)
20968323Ins AStop 324IBEM (G1)
2117659C→ASer to StopICEM (G2)
22165–655–59Del 17bpsplicing variantIAEM (G1)
231004–1014335–338Del 11bpStop 338IIIAEM (G1)
24491164Del AStop 166IIBEM (G1)
800267Del AStop 275
25800267Ins AStop 297IIIAEM (G1)
952–955318–319Del CTTAStop 319
26517173C→TArg to CysIAEM (G1)
27517173C→TArg to CysICEM (G3)
28517173C→TArg to CysIBMixed (EM + C)
29559187Del GStop 198IVBMixed (EM + C)
30750–751250–251Del TGStop 251IAEM (G1)
3117057Ins TStop 62IBEM (G1)
32388130C→GArg to GlyIIICMixed (EM + S + C)
800267Del AStop 275
33190–19164Del CAStop 72IBEM (G1)
952–955318–319Del CTTAStop 319
34820274Del TStop 275ICEM (G1)
35632211Ins GStop 242ICEM (G1)
36640214C→TGln to StopIBEM (G2)
1009337Del TStop 343
1012338T→ASer to Thr
37800267Del AStop 275IAEM (G1)
  • a EM, endometrioid adenocarcinoma; AS, adenosquamous carcinoma; SCC, squamous cell carcinoma; S, serous adenocarcinoma; C, clear cell carcinoma.