Table 3

Summary of toxicities after i.v. administration

ToxicityCTC gradeDose levels/mg/m2 (No. of patients treated)
24 (4)30 (5)37.5 (3)
Nausea1131
2
3211
4
Vomiting121
212
3
4
Anorexia111
211
311
4
Abdominal pain1
211
3
4
Diarrhea134
211
3
41a
Fatigue113
21
32
4
Biochemical liver abnormalities11
21a2a
31a
4
  • a DLT.