Table 4

Pharmacokinetic parameters after i.v. administration of CB1954

Dose (mg/m2)Mean peak concentration μm (SD)Mean t1/2 α mins (SD)Mean t1/2 β mins (SD)Mean AUC μM hr (SD)Clearance ml/min (SD)Volume of distribution liter/m2 (SD)
30.8 (0.2)14 (8)10 (4)0.3 (0.2)958 (443)16.7 (6.3)
61.6 (0.2)11 (11)14 (2)0.5 (0.2)857 (251)15.0 (1.5)
123.0 (0.8)17 (19)39 (19)2.0 (0.9)503 (328)17.0 (5.9)
184.6 (0.4)4 (2)77 (53)4.3 (1.7)307 (100)15.7 (1.3)
246.3 (2.8)9 (13)110 (100)5.8 (3.6)376 (250)18.4 (9.7)
309.3 (5.3)5 (7)78 (56)7.3 (2.6)302 (106)18.3 (12.5)
37.510.2 (4.3)3 (1)136 (78)18.7 (12.2)184 (129)16.1 (5.8)