Table 1

Therapy of human pancreatic carcinoma growing in the pancreas of nude mice

Treatment groupaPancreatic tumorsMetastasisBody weight (g)
IncidenceTumor volume (mm3)
MedianRangeLiverLymphMedianRange
Saline control10/10b574445–7704/10b9/10b2218–30
Gemcitabine10/10230c64–4453/105/102417–26
PKI 166, 7 days/wk10/10162d16–2742/108/102421–31
PKI 166, 7 days/wk + gemcitabine10/1018d6–800/101/1018e15–24
PKI 166, 3 days/wk10/10174c88–6071/107/102521–31
PKI 166, 3 days/wk + gemcitabine10/1027d6–721/103/102215–25
  • a L3.6pl human pancreatic cancer cells (1 × 106) were injected into the pancreas of nude mice. Seven days later, groups of mice were treated with biweekly i.p. injections of gemcitabine (125 mg/kg) alone, daily or triweekly oral feedings of PKI 166 (50 mg/kg) alone, gemcitabine and PKI 166, or saline (control). All mice were killed on day 35.

  • b Number of positive mice/number of mice injected.

  • c P < 0.001 versus control.

  • d P < 0.0001 versus control.

  • e P < 0.01 versus control.