Table 3

Adverse experiences reported in the GIST triala

Initial dose (mg/day)All gradesGrade 3 or 4
Preferred term400 mg (n = 73) %600 mg (n = 74) %400 mg (n = 73) %600 mg (n = 74) %
Fluid retention717663
 Superficial edema717640
 Pleural effusion or ascites6413
Diarrhea566014
Nausea535633
Fatigue333810
Muscle cramps304100
Abdominal pain373773
Skin rash263833
Headache253500
Vomiting222313
Musculoskeletal pain191130
Flatulence162300
Any hemorrhage181958
 Tumor hemorrhage1414
 Cerebral hemorrhage1010
 GI tract hemorrhage6441
Nasopharyngitis121400
Pyrexia12500
Insomnia1100
Back pain111010
Lacrimation increased61100
Upper respiratory tract infection61100
Taste disturbance11400
  • a All adverse events occurring in ≥10% of patients are listed, regardless of suspected relationship to treatment.