Table 1

Effect of ionizing radiation or of ZD1839 treatment on the growth of human cancer cell lines in soft agar

IC50 values were calculated by performing dose-response experiments. Cancer cells were exposed to different doses of ionizing radiation (range, 10–250 cGy) or to different concentrations of ZD1839 (range, 0.01–5 μM) as described in “Materials and Methods.”

Cell lineIonizing radiation IC50 (cGy)ZD1839 IC50m)
GEO1000.1
Calu-61250.15
A5491500.8
OVCAR-3850.15
MCF-7 ADR1100.05