Table 2

Grade 3 and 4 toxicity according to the classification of the WHO among 83 Thal-treated PTs

Adverse effectsNo. of PTs
Grade 3Grade 4
Infection5 (5%)2 (2%)
Tingling or numbness5 (6%)
Deep venous thrombosis3 (4%)
Syncope2 (2%)
Cardiac functiona2 (2%)1 (1%)
Hearing disturbance1 (1%)
Leukocytopenia1 (2%)
  • a Preexisting congestive heart failure that worsened after initiation of Thal therapy (n = 2); myocardial infarction (n = 1).