Table 2

Summary of N-ras codon 61 mutational screening in paired primary and metastatic melanomas

N-ras codon 61 primary tumorsNo. of primary tumorsNo. of corresponding metastases/primary tumorN-ras codon 61 metastases
CAA(Gln)-AAA(Lys) 6 1CAA(Gln)-AAA(Lys)
32CAA(Gln)-AAA(Lys)
CAA(Gln)-CGA(Arg)41CAA(Gln)-CGA(Arg)
12CAA(Gln)-CGA(Arg)
13CAA(Gln)-CGA(Arg)
14CAA(Gln)-CGA(Arg)
16CAA(Gln)-CGA(Arg)
11wt
CAA(Gln)-CAT(His)11CAA(Gln)-CAT(His)
CAA(Gln)-TTA(Leu)11CAA(Gln)-TTA(Leu)
wt24a1wt
42wt
23wt
34wt
15wt
  • a These primary tumors originated from 23 patients; 1 patient had two primary tumors.