p53, EGFR, mdm2, and Ki-67, and status for LTS GBMs
Individual results are given by case number. Results based on immunohistochemistry are scored as “+” or “−”, except for Ki-67, which is expressed as percentage of positive cells. For the p53 gene, the mutation is represented by showing the mutated codon and amino acid change.
| Case | p53 protein | p53 gene | EGFR | mdm2 | Ki-67 |
|---|---|---|---|---|---|
| 1 | + | codon 266 gly→arg | + | + | 50.1 |
| 2 | + | WTa | − | + | 22.9 |
| 3 | + | WT | + | + | 31.3 |
| 4 | + | codon 152 pro→leu | − | + | 35.5 |
| 5 | + | WT | + | + | 16.4 |
| 6 | − | ND | − | − | 5.2 |
| 7 | − | ND | − | − | 24.0 |
| 8 | + | ND | − | − | 3.4 |
| 9 | + | ND | − | − | 11.4 |
| 10 | + | ND | − | − | 3.8 |
| 11 | + | ND | − | − | 16.8 |
| 12 | + | ND | − | − | 16.2 |
| 13 | + | ND | − | + | 12.5 |
| 14 | − | ND | − | − | 15.0 |
| 15 | + | ND | − | − | 6.6 |
| 16 | − | WT | − | + | 68.1 |
| 17 | + | codon 273 arg→cys | − | − | 6.9 |
| 18 | + | ND | − | + | 21.5 |
| 19 | + | WT | − | − | 9.5 |
| 20 | + | ND | − | − | 12.6 |
| 21 | + | ND | − | − | 50.1 |
| 22 | + | WT | − | − | 7.8 |
| 23 | + | WT | − | + | 85.2 |
| 24 | + | ND | − | − | 4.4 |
| 25 | + | WT | − | + | 56.0 |
| 26 | + | ND | − | + | 4.0 |
| 27 | + | WT | − | − | 20.3 |
| 28 | + | WT | − | + | 41.4 |
| 29 | + | ND | + | + | 38.4 |
| 30 | + | codon 280 arg→gly | − | ND | 5.9 |
| 31 | − | ND | − | + | 12.0 |
| 32 | + | WT | − | − | 34.1 |
| 33 | + | WT | + | − | 12.5 |
| 34 | + | ND | − | + | 10.8 |
| 35 | + | ND | − | − | 13.5 |
| 36 | + | WT | − | + | 23.0 |
| 37 | + | codon 250 arg→cys | − | − | 43.4 |
| 38 | + | ND | − | − | 19.0 |
| 39 | + | WT | − | − | ND |
| 40 | + | ND | − | + | 7.9 |
| 41 | − | WT | − | + | 15.2 |
a WT, wild type; ND, not determined because of unamplifiable DNA or unavailable slides.