Table 1

Induction of apoptosis by STI571 in vitro

MG-63 and TE-85 cells were treated with PDGF-BB (10 ng/ml) in the presence or absence of STI571 (1.0 μm). The number of apoptotic cells was determined by in situ TUNEL assay on days 1, 3, and 5 after treatment. The number of apoptotic cells is expressed as a percentage of nonapoptotic cells. SD for all samples was <5%. Statistical analysis was performed by the two-sample t test.

Apoptotic cells (%)
No treatmentPDGFPDGF + STI571STI571
TE-85
 Day 1018a13a
 Day 30110a16a
 Day 50111a21a
MG-63
 Day 1018a14a
 Day 3019a22a
 Day 506a13a24a
  • a P < 0.05, which is considered statistically significant for any treatment group sample when matched to control (no treatment).