Table 2

Plasma pharmacokinetic parameters of LErafAON in mice

SpeciesCmaxa (μg/ml)t1/2α (h)t1/2β (h)AUC0→∞ (μg·h/ml)Cl (liters/h/kg)Vd (liters/kg)
Balb/c nu/nub10.17 ± 2.61.09 ± 0.5326.9 ± 0.9910.12 ± 5.373.45 ± 1.83132.94 ± 66.37
CD2F15.220.4822.509.023.32107.80
  • a Cmax, peak plasma concentration; Vd, volume of distribution.

  • b Values shown are mean ± SD (n = 2).