Table 1

Differences in sensitivity of cancer cell lines and HUVECs to chemotherapeutic agents

Cell population testedAgentIC50 (nm)
MonolayerSpheroid
at 24 hat 72 hat 24 hat 72 h
HUVECsVinblastine0.55N/AN/AN/A
HUVECsAdriamycin1.65N/AN/AN/A
HUVECsCisplatinum4N/AN/AN/A
HUVECsTaxol0.4N/AN/AN/A
MDA-MB-231 parental tumorTaxol24.53,434848
MD22 variantaAdriamycin79.441.51,610260
MPAHS variantaVinblastine15.77.11,349>123,301
MVB9 variantaTaxol27.41910,0841,059
CDDP-S4 variantaCisplatinum2581208327,7732,380
  • a All of the variants are drug-resistant sublines of MDA-MB-231 human breast carcinoma cell line.