Table 1

Mutations in cases and controls

Age (yrs)DataNo. of positive mutationsBRCA1BRCA2No mutation
185delAG5382insC6174delT
<40MSKCCa3 (43%)2104
NA/Ib7 (44%)6019
Control19 (2.7%)928673
40–49MSKCC25 (66%)156413
NA/I21 (44%)136227
Control23 (2.1%)93111090
≥50MSKCC50 (33%)27716102
NA/I41 (34%)1372180
Control20 (1.2%)36111609
  • a MSKCC indicates cases ascertained at Memorial Sloan-Kettering Cancer Center, New York, NY.

  • b NA/I indicates case data from 11 centers in North America and Israel (Moslehi et al., Ref. 12 ).