| AACR Task Force on the Treatment and Prevention of Intraepithelial Neoplasia Subcommittees a |
| Co-Chairs |
| Joyce O’Shaughnessy, M.D., Baylor-Sammons Cancer Center, US Oncology, Dallas, TX |
| Gary J. Kelloff, M.D., DCTD, National Cancer Institute, Bethesda, MD |
| Gary B. Gordon, M.D., Ovation Pharmaceuticals, Lincolnshire, IL |
| Richard Pazdur, M.D., Division of Oncology Drug Products, |
| U.S. Food and Drug Administration, Rockville, MD |
| Background and Conceptual Foundations |
| Gary J. Kelloff, M.D., Chairperson |
| Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD |
| Caroline C. Sigman, Ph.D., Vice Chairperson |
| CCS Associates, Mountain View, CA |
| David L. De Mets, Ph.D. |
| University of Wisconsin, Madison, WI |
| Margaret Foti, Ph.D. |
| AACR, Philadelphia, PA |
| Peter Greenwald, M.D., Dr.P.H. |
| Division of Cancer Prevention, National Cancer Institute, Bethesda, MD |
| Florence Houn, M.D. |
| Office of Drug Evaluation III, U.S. Food and Drug Administration, Rockville, MD |
| Robert J. Temple, M.D. |
| Office of Drug Evaluation, U.S. Food and Drug Administration, Rockville, MD |
| Anthony M. Tremblay |
| AACR, Philadelphia, PA |
| Daniel D. Von Hoff, M.D. |
| Arizona Cancer Center, University of Arizona, Tucson, AZ |
| Prostate and Bladder Cancers |
| Peter T. Scardino, M.D., Chairperson |
| Memorial Sloan-Kettering Cancer Center, New York, NY |
| William G. Nelson, M.D., Ph.D., Vice Chairperson |
| Johns Hopkins Oncology Center, Baltimore, MD |
| Ivan D. Horak, M.D. |
| Pharmacia, Peapack, NJ |
| Ronald Lieberman, M.D. |
| Division of Cancer Prevention, National Cancer Institute, Bethesda, MD |
| Scott M. Lippman, M.D. |
| The University of Texas M. D. Anderson Cancer Center, Houston, TX |
| Wael A. Sakr, M.D. |
| Wayne State University, Harper Hospital, Detroit, MI |
| Dan Shames, M.D. |
| Urologic Drugs, U.S. Food and Drug Administration, Rockville, MD |
| Colorectal Cancer |
| Gary B. Gordon, M.D., Ph.D., Chairperson |
| Ovation Pharmaceuticals, Lincolnshire, IL |
| Monica M. Bertagnolli, M.D., Vice Chairperson |
| Brigham and Women’s Hospital, Boston, MA |
| Carolyn R. Aldige |
| Cancer Research Foundation of America, Alexandria, VA |
| Steven D. Averbuch, M.D. |
| AstraZeneca Pharmaceuticals, Wilmington, DE |
| Mark I. Avigan, M.D. |
| Division of Gastrointestinal and Coagulation Drug Products, U.S. Food and Drug Administration, Rockville, MD |
| Stephen B. Baylin, M.D. |
| Johns Hopkins School of Medicine, Baltimore, MD |
| Charles W. Boone, M.D., Ph.D. |
| Massachusetts Institute of Technology, Cambridge, MA |
| Ernest T. Hawk, M.D., M.P.H. |
| Division of Cancer Prevention, National Cancer Institute, Bethesda, MD |
| Richard Pazdur, M.D. |
| Division of Oncology Drug Products, U. S. Food and Drug Administration, Rockville, MD |
| Lilia Talarico, M.D. |
| Division of Gastrointestinal and Coagulation Drug Products, U.S. Food and Drug Administration, Rockville, MD |
| Breast Cancer |
| Carol J. Fabian, M.D., Chairperson |
| University of Kansas Medical Center, Kansas City, KS |
| Joyce O’Shaughnessy, M.D., Vice Chairperson |
| Baylor-Sammons Cancer Center, US Oncology, Dallas, TX |
| Matthew S. Mayo, Ph.D. |
| University of Kansas Medical Center, Kansas City, KS |
| Robert Milsted, M.D. |
| AstraZeneca Pharmaceuticals, Macclesfield, Cheshire, UK |
| Michael B. Sporn, M.D. |
| Dartmouth Medical School, Hanover, NH |
| Anna Marie V. Storniolo, M.D. |
| Eli Lilly & Company, Indianapolis, IN |
| Frances M. Visco, J.D. |
| National Breast Cancer Coalition, Washington, DC |
| Grant Williams, M.D. |
| Division of Oncology Drug Products, U.S. Food and Drug Administration, Rockville, MD |
| Aerodigestive Cancers |
| Andrew J. Dannenberg, M.D., Chairperson |
| Weill Medical College of Cornell University, Strang Cancer Prevention Center, New York, NY |
| Waun Ki Hong, M.D., Vice Chairperson |
| The University of Texas M.D. Anderson Cancer Center, Houston, TX |
| Steven E. Benner, M.D. |
| Bristol-Myers Squibb, Wallingford, CT |
| Adi F. Gazdar, M.D. |
| University of Texas Southwestern Medical Center, Hamon Cancer Center, Dallas, TX |
| Walter Hittelman, Ph.D. |
| The University of Texas M.D. Anderson Cancer Center, Houston, TX |
| David A. Katzka, M.D. |
| University of Pennsylvania, Philadelphia, PA |
| Stephen Lam, M.D. |
| British Columbia Cancer Center, Vancouver, BC, Canada |
| Beverly D. Lyn-Cook, Ph.D. |
| National Center for Toxicology Research, Jefferson, AR |
| Vali Papadimitrakopoulo, M.D. |
| The University of Texas M.D. Anderson Cancer Center, Houston, TX |
| Anil K. Rustgi, M.D. |
| University of Pennsylvania, Philadelphia, PA |
| Lee W. Wattenberg, M.D. |
| University of Minnesota, Minneapolis, MN |
| Gynecological and Skin Cancers |
| Michele Follen, M.D., Chairperson |
| The University of Texas M.D. Anderson Cancer Center, Houston, TX |
| Frank L. Meyskens, Jr., M.D., F.A.C.P., Vice Chairperson |
| Chao Family Comprehensive Cancer Center, University of California, Irvine, CA |
| David S. Alberts, M.D. |
| Arizona Cancer Center, Tucson, AZ |
| Vicki V. Baker, M.D. |
| Wayne State University and The Karmanos Cancer Institute, Ann Arbor, MI |
| Molly A. Brewer, D.V.M., M.D. |
| The University of Texas Houston Medical School and M.D. Anderson Cancer Center, Houston, TX |
| Patricia Keegen, M.D. |
| Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD |
| David G. Mutch, M.D. |
| Washington University, St. Louis, MO |
| Mack T. Ruffin, M.D., M.P.H. |
| University of Michigan, Ann Arbor, MI |
| Steven P. Stratton, Ph.D. |
| Arizona Cancer Center, University of Arizona, Tucson, AZ |
| Jeffrey S. Weber, M.D., Ph.D. |
| University of Southern California, Los Angeles, CA |
a FDA participation in this Task Force does not represent or imply endorsement of the views of this publication by the Agency or the United States government.