Table 1

Characteristics of 19 patients with multiple HCCa

CaseSexAge (yr)Lagb (mo)HBs-Ag/HCV-AbCirrhosisSize (cm)DiffGenetic status of mitochondrial D-loop regionClinical diagnosis
MutationsC-tract alteration
1M63−/++0.8 × 0.8 × 0.6Mod#72 T > C
0.6 × 0.6 × 0.5Mod#72 T > CM
382 × 1.7 × 1.3Mod#72 T > C?
2M71−/−+11 × 9 × 8Mod53-bp deletion
2 × 1.8 × 1.6Mod10-bp deletionM
102.9 × 2.2 × 1.8Mod 1-bp deletionM
3M59−/++3 × 3 × 3Mod
152.1 × 2 × 1.8Mod?
150.9 × 0.9 × 0.9Mod?
4F57+/−+4 × 3.5 × 3.5Mod 1-bp insertion
1161 × 1 × 0.8Mod 1-bp deletionI
5M61−/++2.5 × 2.3 × 2.1Mod
473 × 2.6 × 2.3Mod 1-bp deletionI
6M36+/−+3 × 3 × 2Mod
653 × 3 × 1ModI
7M68−/++3 × 3 × 3Mod
2.7 × 2.7 × 2.5Mod 1-bp deletionM
8M54−/−10 × 9.5 × 8.5Mod
3 × 3 × 2ModM
9M69−/++4 × 4 × 4Mod
1.5 × 1.5 × 1.5ModM
10M47+/−+8.8 × 8 × 7.5Mod 1-bp deletion
2 × 2 × 1.5Mod 1-bp deletion?
11M49−/++3 × 2.4 × 2.4Mod
3 × 2.2 × 2ModM
12M56−/−5 × 5 × 4.7Mod 5-bp deletion
2.2 × 2 × 1.8ModM
13M72−/++2.5 × 1.8 × 1.5Mod#16209 C > T
2 × 1.6 × 1.2WellI
14M54−/++2 × 2 × 2Mod
0.7 × 0.6 × 0.6Well#16278 T > C, #431 1-bp insertionI
15M65−/++4.5 × 4 × 4Mod10-bp deletion
4.5 × 3.5 × 3ModM
16F63−/++3 × 2.4 × 2Mod#16390 G > A
2 × 1.7 × 1.5ModM
17M56−/++1.9 × 1.2 × 1.2Mod 1-bp deletion
1.4 × 1.2 × 1.2Mod 1-bp deletionM
1.3 × 1.2 × 1.1ModM
18F66−/++2.2 × 1.9 × 1.8Mod
1.6 × 1.4 × 1.4ModM
19M60−/++3.6 × 3.4 × 3Poor#70 G > A
2.4 × 2.2 × 2ModI
  • a M, metastasis; I, independent lesion; ?, indeterminate.

  • b The largest tumor in the first operation was listed as the first primary lesion. Lag means the time between the first and second operation (mo = month). Clinical diagnosis was determined based on the Classification of Primary Liver Cancer in Japan (28) .