Table 2

Neurotoxicity in patients treated with crotoxin

Dose (mg/m²)	Days of treatment	Neurotoxicity^a grade (study days)
Dose (mg/m²)	Days of treatment			Diplopia^b	Palpebral ptosis	Nystagmus	Anxiety
0.18	30	2 (9–19)	—	—	—
0.18	30	2 (6–14)
0.18	30	2 (2–10)
0.21	30	2 (2–20)
0.21	30	2 (1–14)
0.21	90	2 (11–21)
0.22	30	2 (2–4)	(19–22)	2 (15–16)	2 (15), 3 (16)
0.22	90	2 (6–14)	—	2 (16–17)	3 (17)
0.22	30	2 (8)	—	—	—
0.22	30	2 (4, 5)
0.22	30	2 (2–21)	(18–20)	2 (15)	3 (15)
0.22	30	2 (8–21)	(12–18)	2 (19–20)	2 (19); 3 (20)
0.21	2		Died on study day 3^c
0.21	90	2 (2–21)
0.21	60	2 (2–11)
0.21	90	2 (1–5)
0.21	30	2 (10–21)	Discharged on study day 31^d
0.21	8	2 (4–5)	Abandoned protocol on day 8^e

^a No neural toxicity was observed at doses up to 0.18 mg/m².
^b Diplopia appeared intermittently within the study days indicated in parenthesis.
^c This patient died on study day 3 of pulmonary edema.
^d Patient had a mild allergic reaction on study day 3 and a grade 3 anaphylactic reaction on day 31.
^e Patient abandoned the protocol on study day 8, unable to adapt to the obligatory in-patient condition required by this study.