Table 2

Neurotoxicity in patients treated with crotoxin

Dose (mg/m2)Days of treatmentNeurotoxicitya grade (study days)
DiplopiabPalpebral ptosisNystagmusAnxiety
0.18302 (9–19)
0.18302 (6–14)
0.18302 (2–10)
0.21302 (2–20)
0.21302 (1–14)
0.21902 (11–21)
0.22302 (2–4)(19–22)2 (15–16)2 (15), 3 (16)
0.22902 (6–14)2 (16–17)3 (17)
0.22302 (8)
0.22302 (4, 5)
0.22302 (2–21)(18–20)2 (15)3 (15)
0.22302 (8–21)(12–18)2 (19–20)2 (19); 3 (20)
0.212Died on study day 3c
0.21902 (2–21)
0.21602 (2–11)
0.21902 (1–5)
0.21302 (10–21)Discharged on study day 31d
0.2182 (4–5)Abandoned protocol on day 8e
  • a No neural toxicity was observed at doses up to 0.18 mg/m2.

  • b Diplopia appeared intermittently within the study days indicated in parenthesis.

  • c This patient died on study day 3 of pulmonary edema.

  • d Patient had a mild allergic reaction on study day 3 and a grade 3 anaphylactic reaction on day 31.

  • e Patient abandoned the protocol on study day 8, unable to adapt to the obligatory in-patient condition required by this study.