Pharmacokinetic parameters of crotoxin administered i.m. to patients at the dose of 0.21 mg/m2 on study days 1 and 15
| Parameter (units) | Day 1 × (± SD) | Day 15 × (± SD) |
|---|---|---|
| aC (ng/ml−1) | 1.53 (±0.14) | 1.63 (±0.12) |
| aKA (min−1) | 0.121 (±0.003) | 0.173 (±0.002) |
| at1/2A (min) | 5.2 (±0.6) | 4.8 (±0.3) |
| bA (ng/ml−1) | 1.11 (±0.16) | 1.2 (±0.2) |
| bα (min−1) | 0.032 (±0.01) | 0.038 (±0.02) |
| bt1/2α (min) | 22 (±3) | 18.2 (±4.2) |
| cB (ng/ml−1) | 0.38 (±0.12) | 0.38 (±0.10) |
| cβ (h−1) | 0.136 (±0.03) | 0.163 (±0.03) |
| ct1/2 β (h) | 5.2 (±0.6) | 4.3 (±0.6) |
| dCl (ml/min−1) | 26.0 (±8) | 25.5 (±5) |
| AUC (μg/min/ml−1) | 0.190 (±0.05) | 0.196 (±0.03) |
| eVd (liter/kg−1) | 12 (±3) | 9.1 (±4) |
a C, KA, and t1/2A are the coefficient, rate constant, and half-life for the absorption phase, respectively.
b A, α, and t1/2α are the coefficient, rate constant, and half-life for the distribution phase, respectively.
c B, β, and t1/2β are the coefficient, rate constant, and half-life for the elimination phase, respectively.
d Cl = Clearance.
e Vd, apparent volume of distribution.