Parameter (units) | Day 1 × (± SD) | Day 15 × (± SD) |
---|---|---|
^{a}C (ng/ml^{−1}) | 1.53 (±0.14) | 1.63 (±0.12) |
^{a}K_{A} (min^{−1}) | 0.121 (±0.003) | 0.173 (±0.002) |
^{a}t_{1/2A} (min) | 5.2 (±0.6) | 4.8 (±0.3) |
^{b}A (ng/ml^{−1}) | 1.11 (±0.16) | 1.2 (±0.2) |
^{b}α (min^{−1}) | 0.032 (±0.01) | 0.038 (±0.02) |
^{b}t_{1/2α} (min) | 22 (±3) | 18.2 (±4.2) |
^{c}B (ng/ml^{−1}) | 0.38 (±0.12) | 0.38 (±0.10) |
^{c}β (h^{−1}) | 0.136 (±0.03) | 0.163 (±0.03) |
^{c}t_{1/2} β (h) | 5.2 (±0.6) | 4.3 (±0.6) |
^{d}C_{l} (ml/min^{−1}) | 26.0 (±8) | 25.5 (±5) |
AUC (μg/min/ml^{−1}) | 0.190 (±0.05) | 0.196 (±0.03) |
^{e}V_{d} (liter/kg^{−1}) | 12 (±3) | 9.1 (±4) |
^{a} C, K_{A}, and t_{1/2A} are the coefficient, rate constant, and half-life for the absorption phase, respectively.
^{b} A, α, and t_{1/2α} are the coefficient, rate constant, and half-life for the distribution phase, respectively.
^{c} B, β, and t_{1/2β} are the coefficient, rate constant, and half-life for the elimination phase, respectively.
^{d} C_{l} = Clearance.
^{e} V_{d}, apparent volume of distribution.