Table 4

Pharmacokinetic parameters of crotoxin administered i.m. to patients at the dose of 0.21 mg/m2 on study days 1 and 15

Parameter (units)Day 1 × (± SD)Day 15 × (± SD)
aC (ng/ml−1)1.53 (±0.14)1.63 (±0.12)
aKA (min−1)0.121 (±0.003)0.173 (±0.002)
at1/2A (min)5.2 (±0.6)4.8 (±0.3)
bA (ng/ml−1)1.11 (±0.16)1.2 (±0.2)
bα (min−1)0.032 (±0.01)0.038 (±0.02)
bt1/2α (min)22 (±3)18.2 (±4.2)
cB (ng/ml−1)0.38 (±0.12)0.38 (±0.10)
cβ (h−1)0.136 (±0.03)0.163 (±0.03)
ct1/2 β (h)5.2 (±0.6)4.3 (±0.6)
dCl (ml/min−1)26.0 (±8)25.5 (±5)
AUC (μg/min/ml−1)0.190 (±0.05)0.196 (±0.03)
eVd (liter/kg−1)12 (±3)9.1 (±4)
  • a C, KA, and t1/2A are the coefficient, rate constant, and half-life for the absorption phase, respectively.

  • b A, α, and t1/2α are the coefficient, rate constant, and half-life for the distribution phase, respectively.

  • c B, β, and t1/2β are the coefficient, rate constant, and half-life for the elimination phase, respectively.

  • d Cl = Clearance.

  • e Vd, apparent volume of distribution.