Table 2

Dose cohorts and length of therapy

CohortStarting dose (mg/kg/day)No. of patientsNo. of dose reductionsDuration of therapy (no. of cycles)Best response
11.030, 0, 011, 7, 4PR, PR, SD
21.530, 0, 1 (cycle 4)2, 8, 6PD, SD, SDa
32.090, 1 (cycle 2), 0, 1 (cycle 2), 0, 0, 0, 0, 1 (cycle 2)4, 3, 1, 10, 1, 1, 3, 4, 2SD, SD, PD, SD, PD, PD, SD,a SD, PD
  • a Reduction in tumor size did not meet criteria for PR.