Table 6

ISIS 3521 Css determination

Dose (mg/kg/day)Parameter descriptionISIS 3521 plasma concentration (μg/ml)% Intact
1.0aISIS 3521 Css alone0.34886.11
ISIS 3521 Css with 5-FUb0.342100
1.5cISIS 3521 Css alone0.367 ± 0.12775.88 ± 22.70
ISIS 3521 Css with 5-FUb0.321 ± 0.07865.24 ± 24.65
2.0dISIS 3521 Css alone0.717 ± 0.56277.10 ± 17.06
ISIS 3521 Css with 5-FUb0.561 ± 0.26774.66 ± 17/45
  • a n = 2 patients.

  • b Average concentration of ISIS 3521 in the presence of 5-FU (includes 10, 20, 30, 60, and 90 min after 5-FU dose).

  • c n = 3 patients.

  • d n = 8 patients without 5-FU and 7 patients with 5-FU.