Table 7

5-FU PK measurements (N = 13)

Estimates are presented as the average (SD) of the individual pharmacokinetic estimates.

5-FU pharmacokinetic parameterWithout ISIS 3521With ISIS 3521Pa
AUC (ng*h/ml)9342.2 (2402.5)10637.4 (2602.4)0.08
CL (liter/h/m2)48.4 (12.4)42.9 (13.6)0.23
t1/2 (h)0.17 (0.05)0.20 (0.04)0.06
Vss (liter/m2)11.3 (4.9)11.2 (3.8)0.95
  • a Paired t-test (SPSS).