Table 2

Comparison of topoisomerase IIα amplification and overexpression

Copy number of topoisomerase IIα was measured by FISH; tumors with topoisomerase IIα:CEP-17 ratio greater than 2.5 were considered amplified. Topoisomerase IIα expression in the nucleus was measured by immunohistochemistry. There was no evidence for an association between topoisomerase IIα overexpression and gene amplification (P = 0.635).

Topoisomerase overexpressedTopoisomerase not overexpressed
Topoisomerase amplified24
Topoisomerase not amplified722
Total patients926