Table 3

Amplification of erbB-2 is related to chemotherapy response

Copy number of erbB-2, as determined by FISH, was significantly associated with local tumor response to chemotherapy (P = 0.008). If CR or MRD versus all other responses are compared, P = 0.007. Response was determined by comparison of the breast tumor at presentation with the mastectomy specimen.

CR or MRDPRSTD or PD
erbB-2 amplified530
erbB-2 not amplified3168
Total patients8198