Table 7

Overexpression of topoisomerase IIα is associated with chemotherapy response

Topoisomerase IIα overexpression was significantly associated with favorable chemotherapy response (P = 0.021). If patients with CR or MRD versus all of the other responses are compared, P = 0.015. Response was determined by comparison of the breast tumor at presentation with the mastectomy specimen.

CR or MRDPRSTD or PD
Topoisomerase overexpressed522
Topoisomerase not overexpressed3176
Total patients8198