In vitro effects of exisulind and docetaxel alone and in combination on cell cycle distribution and % of apoptotic cells in A549 NSCLC cells
Treatment | % G1a | % S | % G2-M | % Apoptosis |
---|---|---|---|---|
Control 24 h | 46 | 38 | 16 | 0 |
Exi 200 μm | 60 | 22 | 18 | 0.1 |
Exi 300 μm | 65 | 14 | 21 | 0 |
Doce 0.2 nm | 42 | 39 | 19 | 0 |
Doce 0.5 nm | 38 | 41 | 21 | 0.05 |
Doce 1 nm | 46 | 40 | 14 | 0.58 |
Doce 3 nm | 32 | 57 | 11 | 11 |
Control 12 h | 51 | 33 | 16 | 0 |
Docetaxel 6 nm | 30 | 50 | 20 | 34 |
Docetaxel 10 nm | 10 | 51 | 39 | 64 |
Control 24 h | 46 | 38 | 16 | 0 |
Exi 200 μm + Doce 0.2 nm | 59 | 21 | 20 | 0.47 |
Exi 200 μm + Doce 0.5 nm | 54 | 28 | 19 | 9.4 |
Exi 200 μm + Doce 1 nm | 46 | 8 | 46 | 5 |
Exi 300 μm + Doce 0.2 nm | 58 | 17 | 25 | 5 |
Exi 300 μm + Doce 0.5 nm | 43 | 24 | 33 | 39 |
Exi 300 μm + Doce 1 nm | 51 | 36 | 13 | 62 |
a Exi, exisulind; Doce, docetaxel; % Apoptosis, percentage of apoptotic cells.