Table 2

Effect of exisulind, docetaxel, and the combination on the number of athymic rats with metastases from orthotopic A549 tumors (first experiment)

TreatmentDose and scheduleMean survival days (P, log-rank)# rats with mets/# treated (P, Fisher’s exact test)
Control43 days9/10
Exisulind50 mg/kg daily52.5 days7/8
(P = 0.49)(P = 1.0)
Exisulind100 mg/kg daily57.625 days7/8
(P = 0.26)(P = 1.0)
Docetaxela5 mg/kg (2×/wk)63.5 days6/8
2.5 mg/kg/wk (4×)(P = 0.058)(P = 0.56)
Docetaxela10 mg/kg (2×/1 wk)63.25 days5/8
5 mg/kg/wk (4×)(P = 0.038)(P = 0.27)
Exisulind50 mg/kg daily>80 days1/8
Docetaxela5 mg/kg (2×/wk)(P < 0.001)(P = 0.003)
2.5 mg/kg/wk (4×)
Exisulind50 mg/kg daily62.375 days3/8
Docetaxela10 mg/kg (2×/wk)(P = 0.12)(P = 0.043)
5 mg/kg/wk (4×)
Exisulind100 mg/kg daily43.375 days4/8
Docetaxela5 mg/kg (2×/wk)(P = 0.99)(P = 0.12)
2.5 mg/kg/wk (4×)
Exisulind100 mg/kg daily49 days3/8
Docetaxela10 mg/kg (2×/wk)(P = 0.40)(P = 0.043)
5 mg/kg/wk (4×)
  • a Docetaxel was administered at the higher dose twice in the first week and once weekly at the lower dose for the next 4 weeks.