Table 2

IC50 values for [D-Phe6, β-Ala11, Phe13, Nle14]bombesin(6–14) (univ.BN), bombesin, GRP, and NMB measured in three groups of tumors expressing preferentially GRP-, NMB-, or BB3-receptors

Tumor groupIC50 (nM) mean ± SEM
univ.BNBombesinGRPNMB
Group 1: GRP receptor-expressing tumors (4 prostate and 3 breast carcinomas)1.4 ± 0.25 ± 1.12.6 ± 0.5366 ± 75
Group 2: BB3 receptor-expressing tumors (6 bronchial carcinoids)2.1 ± 0.7>10.000>10.000269 ± 45
Group 3: NMB receptor-expressing tumors (4 gut and 1 thymic carcinoids)1.9 ± 0.319 ± 3.2304 ± 430.67 ± 0.2