Table 1

Plasma pharmacokinetics of anti-HER2 immunoliposome-dox in rats

Anti-HER2 immunoliposomes (0–7 mol % PEG; Ls-MAb or PEG-MAb linkage) were loaded with dox and administered i.v. at a dose of 5.0 μmol of total lipid (0.8–1.0 mg of dox).

Immunoliposome typeTerminal t1/2 (h)AUCa (min %)MRT ± SE (h)
0% PEG, Ls-MAb11.670,95415.8 ± 1.1
1% PEG, Ls-MAb13.485,69519.3 ± 3.2
2% PEG, Ls-MAb12.757,53917.7 ± 3.0
7% PEG, PEG-MAb16.393,13324.3 ± 0.9
Liposome: 1% PEG, no MAb13.669,88220.7 ± 1.2
  • a AUC, area under the curve; MRT, mean residual time.