Table 2

Methylation status of tumor plasma DNA

Statistical associations between bladder cancer cases with DNA plasma alterations (p14ARF promoter hypermethylation or microsatellite changes) and cases with no alterations regarding various clinicopathological parameters.

Plasma p14ARF methylNo plasma p14ARF methylP
na%n%
No. of patients1314
Multicentric foci
 Yes1310010710.036
 No00429
Tumor Size
 ≤3005360.01
 >313100964
Relapse
 Yes9694290.03
 No4311071
LNE
 Positive323000.05
 Negative107714100
Invasion
 Ta–T186213930.05
 T2–T453817
Treatment
 TUR/IT1077141000.05
 Cystectomy32300
Stage
 0a–II86213930.05
 III–IV53817
Allelic losses in tumor plasma DNA
Plasma LOHNo plasma LOHP
n%n%
No. of patients1611
Relapse
 Yes1062.52180.02
 No637.5982
  • a n, number of cases; LNE, lymph node enlargement; IT, intravesical therapy.