Table 1

Inhibition of anchorage-independent growth by HDAC inhibitors

Cells were cloned in soft agarose in the continuous presence of the vehicle DMSO, TSA, or PB, and colonies were counted after 10 or 14 days (A549 and H157, respectively).

Cell lineNo. of colonies (% of control)
DMSOTSA 250 nmTSA 100 nmPB 2 mm
A549387 ± 64 (100%)1.7 ± 1.7 (0%)0 ± 0 (0%)5.3 ± 1.2 (0%)
H157162 ± 4 (100%)1 ± 0.8 (0%)1.3 ± 0.9 (0%)0 ± 0 (0%)