Table 1

DNA and amino acids sequences of CDR3 heavy chain RFB4

The nucleotide and amino acid sequence of the entire CDR3 heavy chain is shown. Hot spots with the sequence Pu-G-Py-A/T are underlined. The amino acids mutagenized are in bold. The residues are numbered according to the Kabat database (21) .

9596979899100100A100B100C100D100E100F101102
HSGY G S S Y GVLFAY
CATAGT GGC TAC GGT AGTAGCTACGGG GTT TTGTTTGCTTAC