Table 4

Nonhematologic toxicity by dose levela

ToxicityLevel 0 (n = 4)Level 1 (n = 3)Level 2 (n = 6)Level 3 (n = 6)
Grade 1 or 2Grade 3Grade 1 or 2Grade 3Grade 1 or 2Grade 3Grade 1 or 2Grade 3
Sensory neuropathy00004133
Ocular10002022
Stomatitis00104032
Nausea10103041
Vomiting10100021
Diarrhea10203011
Arthralgia/myalgia30304041
Skin00005020
Fever (non-neutropenic)00002030
  • a Expressed as the number of patients experiencing the toxic effect during the first two cycles of treatment.