Nonhematologic toxicity by dose levela
| Toxicity | Level 0 (n = 4) | Level 1 (n = 3) | Level 2 (n = 6) | Level 3 (n = 6) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Grade 1 or 2 | Grade 3 | Grade 1 or 2 | Grade 3 | Grade 1 or 2 | Grade 3 | Grade 1 or 2 | Grade 3 | |||||
| Sensory neuropathy | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 3 | ||||
| Ocular | 1 | 0 | 0 | 0 | 2 | 0 | 2 | 2 | ||||
| Stomatitis | 0 | 0 | 1 | 0 | 4 | 0 | 3 | 2 | ||||
| Nausea | 1 | 0 | 1 | 0 | 3 | 0 | 4 | 1 | ||||
| Vomiting | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | ||||
| Diarrhea | 1 | 0 | 2 | 0 | 3 | 0 | 1 | 1 | ||||
| Arthralgia/myalgia | 3 | 0 | 3 | 0 | 4 | 0 | 4 | 1 | ||||
| Skin | 0 | 0 | 0 | 0 | 5 | 0 | 2 | 0 | ||||
| Fever (non-neutropenic) | 0 | 0 | 0 | 0 | 2 | 0 | 3 | 0 | ||||
a Expressed as the number of patients experiencing the toxic effect during the first two cycles of treatment.