Table 5

Summary of noncompartmental pharmacokinetic parameters, mean (% coefficient of variation) values by dosea

Dose mg/m2Infusion duration minnCmax ng/mlAUCinf ng/h/mlHalf-life hCL liter/h/m2Vz liter/m2
13518031392 (30)5654 (42)12.9 (60)27.4 (45)418 (32)
1353016100642714.621.1442
2003037757 (35)9613 (20)13.4 (67)21.4 (21)384 (64)
30030513520 (7)17610 (21)14.6 (14)17.7 (22)370 (23)
37530419350 (15)35805 (40)13.2 (12)11.9 (42)236 (54)
  • a n, number of patients; Cmax, maximum or peak concentration; AUCinf, area under the whole blood/plasma concentration-time curve from time 0 to time infinity; CL, total body clearance; Vz, volume of distribution.