Table 1

Effect of continuous and intermittent dosing schedules of 17:AAG on the growth of CWR22, CWR22R and CWRSA6 xenografts.

TumorDose (mg/kg)Dosing regimenPercent (%) Inhibition (day)P
CWR2225Continuous42 (24)<0.01
50Continuous67 (24)<0.01
50Intermittent51 (25)0.01
CWRSA625Continuous56 (29)0.07
50Continuous80 (29)<0.01
50Intermittent87 (30)<0.01
CWR22R25Continuous49 (21)0.01
50Continuous68 (21)0.02
50Intermittent67 (22)<0.01