Table 1

Combination therapy with IMC-C225 and CPT-11

Fractional tumor volume (FTV)a relative to control animals
Combination Therapy
DaybIMC-C225CPT-11ExpectedcObservedRatio of expected: observed FTVd
DLD-1260.5770.4470.2580.2541.015
290.5790.4100.2370.2131.111
330.5340.3650.1950.1531.272
360.5060.3560.1800.1331.349
HT-29250.4810.3930.1890.1621.166
280.4560.3600.1640.1201.364
320.4090.3100.1270.0781.638
350.4110.2910.1200.0542.232
  • a FTV, calculated as mean tumor volume experimental/mean tumor volume control.

  • b Day after start of treatment. Tumor volumes were measured twice weekly (n = 8 for each group of mice).

  • c (Mean FTV of IMC-C225) × (mean FTV of CPT-11).

  • d Obtained by dividing the expected FTV by the observed FTV. A ratio of >1 indicates a more than additive effect, and a ratio of <1 indicates a less than additive effect.