Table 2

Mean 96-h IC50 and resistance factors to a variety of anticancer drugs and signal transduction inhibitorsa

KM12KM12/R115Resistance factor
R115777 (μm)0.23 ± 0.163.26 ± 1.8813.00 ± 2.55*
FTI-277 (μm)0.615 ± 0.617.40 ± 3.2214.51 ± 9.58*
GGTI-298 (μm)3.36 ± 1.112.11 ± 0.440.76 ± 0.31
Doxorubicin (μm)0.043 ± 0.0210.004 ± 0.00480.08 ± 0.06*
Cisplatin (μm)43.00 ± 22.3811.68 ± 7.300.34 ± 0.34*
Paclitaxel (nm)2.95 ± 1.453.14 ± 0.971.42 ± 0.94
Etoposide (μm)0.066 ± 0.0260.061 ± 0.0300.85 ± 0.42
UO126 (μm)3.97 ± 0.355.10 ± 0.851.30 ± 0.26
LY294002 (μm)4.30 ± 0.614.60 ± 0.791.10 ± 0.37
PD153035 (μm)4.13 ± 0.214.73 ± 0.761.15 ± 0.25
  • a Data are given as mean ± SD; the resistance factor was calculated by the IC50 of KM12-R115/IC50 of KM12 for each experiment; n ≥ 3;

  • * = statistically significant (P < 0.05).