Table 1

Clinical characteristics of 57 PGL patients evaluated for SDHD mutations

CharacteristicAll patients (N = 57)Patients with positive family historya (N = 19)Patients with negative family historya (N = 38)Pb
Patient
 Sex [no. (%)]0.56
  Male21 (37)8 (42)13 (34)
  Female36 (63)11 (58)25 (66)
 Mean age of onset± SE (yrs)42.4± 12.437.3± 8.245.0± 14.10.04
 Mean follow-up time [months (range)]52 (1–218)57 (1–166)49 (1–218)0.56
Tumor focality [no. (%)]<0.0001c
 Single PGL30 (53)2 (10)28 (74)
  Recurrence7 (12)7 (18)
 Bilateral carotid body10 (17)7 (37)3 (8)
 Multiple17 (30)10 (53)7 (18)
Site of tumor [no. (%)]N = 105N = 51N = 54
 Carotid body55 (52)33 (64)22 (41)0.17
 Vegal nerve17 (16)8 (16)9 (17)
 Tympanic nerve15 (14)3 (6)12 (22)0.035
 Jugular nerve13 (13)6 (12)7 (13)
 Mediastinal4 (4)1 (2)3 (5)
 Spinal cord1 (1)0 (0)1 (2)
  • a Family history data as reported at the time of the original interview.

  • b We used the χ2 test to compare all variables except mean age at onset and mean follow-up time, for which we used an unpaired t test.

  • c P is for comparison of single PGL with bilateral and multiple PGL.