Table 1

Growth inhibition and induction of apoptosis by the PI3K inhibitor LY294002 in human colon cancer xenografts

DLD-1LoVo
MeanSDPaMeanSDPa
Tumor volume (×103 mm3)b
  Control2.3300.5440.0221.4330.4510.011
  LY2940021.5910.1200.6460.176
ABIc
  Control11.43.970.67619.06.40<0.001
  LY29400212.44.66139.416.41
<0.001
  • a Ps for tumor volume and ABI were estimated by the Mann-Whitney U test and the χ2 test, respectively.

  • b Tumor volume (V) was calculated as V = A × B2, where A is the width of the tumor in millimeters and B is the length, as described in “Materials and Methods.” The mean tumor volumes of the DLD-1 and LoVo xenografts at day 0 were 1.230 ± 0.333 × 103 and 0.822 ± 0.101 ×103 mm3, respectively.

  • c ABI was determined by counting the number of ssDNA-positive cells in a total of 10 high power fields (×400).