DLD-1 | LoVo | |||||
---|---|---|---|---|---|---|

Mean | SD | P^{a} | Mean | SD | P^{a} | |

Tumor volume (×10^{3} mm^{3})^{b} | ||||||

Control | 2.330 | 0.544 | 0.022 | 1.433 | 0.451 | 0.011 |

LY294002 | 1.591 | 0.120 | 0.646 | 0.176 | ||

ABI^{c} | ||||||

Control | 11.4 | 3.97 | 0.676 | 19.0 | 6.40 | <0.001 |

LY294002 | 12.4 | 4.66 | 139.4 | 16.41 | ||

<0.001 |

^{a}*P*s for tumor volume and ABI were estimated by the Mann-Whitney*U*test and the χ^{2}test, respectively.^{b}Tumor volume (*V*) was calculated as V = A × B^{2}, where*A*is the width of the tumor in millimeters and*B*is the length, as described in “Materials and Methods.” The mean tumor volumes of the DLD-1 and LoVo xenografts at day 0 were 1.230 ± 0.333 × 10^{3}and 0.822 ± 0.101 ×10^{3}mm^{3}, respectively.^{c}ABI was determined by counting the number of ssDNA-positive cells in a total of 10 high power fields (×400).