Table 2

Hematologic and nonhematologic toxic effects: worst by patient

ToxicityISIS 3512 (n = 19)ISIS 5132 (n = 18)
Gr 1234TotalGr 1234Total
Fatigue671366113
Anorexia3115224
Nausea224415
Vomiting21311
Stomatitis21322
Diarrhea1122
Infection011
Altered mood1120
Granulocytes00
Hemoglobin94136410
Platelets415415
Creatinine2233
AST (all pts)5275218
AST (pts without liver metastases, n = 9)022
  • a Nonhematologic effects included are those possible, probably, or definitely drug related.