Table 3

Summary of plasma concentrations of ISIS 3521 and ISIS 5132

ISIS drugSample dayNo. patientsParent plasma concentration (μg/ml)aTotal plasma concentration (μg/ml)% Intactb
3521890.880± 0.6701.200± 0.85568.01± 14.85
1560.546± 0.3160.789± 0.52660.50± 7.75
22111.250± 1.8091.433± 1.74655.43± 3.95
Cssc0.892± 0.3521.141± 0.326
5132860.642± 0.5200.870± 0.85370.31± 11.31
1561.142± 1.4611.256± 1.48361.49
2290.565± 0.4420.782± 0.77570.60± 6.47
Css0.783± 0.3130.969± 0.252
  • a 1 μg/ml = 142.86 nM.

  • b Not all patients could be analysed for % intact.

  • c Average concentration of days 8, 15, and 22.