Table 1

Correlation of RASSF1A methylation with clinicopathological characteristics in patients with stage I lung adenocarcinomas

Clinicopathological featureSubsetNo. of RASSF1A methylation (%)Pa
+
GenderMale24 (38)40 (62)0.1506
Female11 (24)35 (76)
Age<6014 (34)27 (66)0.8326
60–6912 (31)27 (69)
>699 (30)21 (70)
Smoking historySmoker22 (35)40 (65)0.4117
Nonsmoker13 (27)35 (73)
T stageT123 (31)52 (69)0.8264
T212 (34)23 (66)
DifferentiationPoorly11 (65)6 (35)0.0005 (poorly vs. well)
Moderately14 (38)23 (62)0.0835 (poorly vs. moderately)
Well10 (18)46 (82)
Vascular invasion+15 (48)16 (52)0.0242
20 (25)59 (75)
Lymphatic permeation+7 (32)15 (68)>0.9999
28 (32)60 (68)
Pleural involvement+13 (50)13 (50)0.0305
22 (26)62 (74)
Histologic typing of small adenocarcinoma of the lungbA0 (0)3 (100)0.2585 (A, B vs. C, D)
B2 (25)6 (75)
C5 (28)13 (72)
D4 (100)0 (0)
E00
F1 (50)1 (50)
  • a Fisher’s exact test.

  • b Ref. 25 , the greatest dimension of the tumor is ≤2 cm.