Table 4

Nonhematological toxicities

Dose Levels (mg/m2), no. of patientsTotal no. of cyclesNauseaVomitingDiarrheaFatigueFeverRashPruritsNeuropathy- SensoryHeadache
123412341234123412341234123412341234
0.13, n = 36000000000000000000000000000000000000
0.25, n = 49000000000000100000000000000000000000
0.40, n = 58000000000000000001000000000000000000
0.60, n = 48000000000000020020000000000000000000
0.75, n = 39000000001000000000000000000000000000
0.90, n = 617100010001000110010000100100000000000
1.08, n = 36000000000000000011001000000010000000
1.30, n = 37000000001000010000000000000000100000
1.56, n = 1219810051001420630030001000010001206000