Parameter description | Population^{a} estimate (% SEE) | Interpatient^{b} variability (% SEE) |
---|---|---|
Clearance | ||
Parameter for CL (liters/h) | 51.5 (6.4) | 32% (38) |
Effect of ALT on CL^{c} | −0.132 (84.1) | |
Effect of BSA on CL^{c} | 1.06 (43) | |
V | ||
Parameter for V (liters) | 131 (8.9) | 39% (29) |
Effect of BSA on V^{d} | 1.93 (29) | |
Residual error | ||
Proportional^{e} | 51 (10) |
^{a} Pharmacokinetic database: 36 subjects; 287 observations. SEE, SE of the estimate.
^{b} Exponential error model; results represented as a percentage coefficient of variation.
^{c}
^{d}
^{e} The difference between model-predicted cryptophycin plasma concentration and observed concentration was modeled as Cij = Csij × (1+ (εij)). The value includes intrasubject variability, model misspecification, and any errors in blood sampling (phlebotomy) times.