Table 3

Summary of steady-state concentrations of ISIS 3521 and ISIS 5132a

AgentSample dayNo. patientsParent oligonucleotide (μg/ml)Total oligonucleotide (μg/ml)% Intact
ISIS 3521870.92 ± 0.371.70 ± 0.7454.27 ± 4.07
1580.98 ± 0.611.78 ± 1.0054.51 ± 6.37
2270.76 ± 0.271.42 ± 0.6656.05 ± 9.79
Mean Cssb0.89 ± 0.431.65 ± 0.79
ISIS 5132870.73 ± 0.341.20 ± 0.6461.88 ± 7.94
15110.61 ± 0.331.08 ± 0.5657.46 ± 10.31
22110.60 ± 0.301.05 ± 0.5758.14 ± 11.48
Mean Cssb0.63 ± 0.311.10 ± 0.57
  • a Values represent means (± SD).

  • b Mean Css, average concentration of days 8, 15, and 22.