Table 2

The nucleotide and aa changes observed in the EBNA-1 gene sequence from the primary tumor of all 13 NPC patients relative to B95-8 cell line

Nucleotide no.Nucleotide changeaa no.aa change
107995G→C16E→Q
108002G→A18G→E
108007A→T20T→S
108057T→G36no change
108117C→T56no change
108972T→C341no change
109039∼109041GGA→AGG364G→R
109080A→T377no change
109182A→T411E→D
109202A→T418H→L
109264G→A439A→T
109409C→T487A→V
109446C→G499D→E
109454C→A502T→N
109509A→C520no change
109520C→T524T→I
109531A→G528I→V
109546C→A533L→I
109608G→A553no change
109703aC→T585T→I
109730G→A594R→K
  • a Only 2 of 13 tumor samples exhibit this point mutation.