Table 2

The resistance of glioma cell lines to TMZ depends on MGMT

Cell lineMGMTIC50(10) (TMZ)IC50(10) (TMZ + BG)
SWB95109a100b (880)50 (350)c
SWB7775350 (>1000)300 (800)c
SWB335675 (120)54 (100)
SWB404548 (80)50 (100)
SWB3910125 (330)110 (235)
SWB611630 (50)35 (50)
D54596 (135)87 (110)
  • a MGMT level (fmol/mg protein).

  • b μm.

  • c Statistically significant as compared to BG untreated (<0.05).