Table 4

Effect of cell cycle arrest on apoptosis in glial cell tumor cells (in vitro)

Cell lineAgentaCell cycle arrestApoptotic index
wt p53
 SWB54TMZ+55
 SWB40TMZ+89
 SWB61TMZ+126
Mutant p53
 SWB33TMZ+43
 SWB95TMZ+91
 SWB39TMZ29
 SWB77TMZ18
  • a Toxicity assays were performed at 100 μm TMZ for all lines except for SWB77 and SWB95, which were treated with 200 μm TMZ. All cells were pretreated with BG to neutralize MGMT.