Table 2

Number of courses administered by dose level and occurrence of DLT

Dose levelFirst courseSubsequent coursesTotal coursesDay 8 omittedDay 15 omittedCourses with omissionsaDLT occurrence
 7 mg/m2101000
14 mg/m2112000
28 mg/m261218144 (0)
40 mg/m217496682529 (13)Diarrhea (1)
Diarrhea + febrile neutropenia (1)
Febrile neutropenia (1)
50 mg/m2184563124247 (35)Diarrhea (1)
Febrile neutropenia (2)
60 mg/m2213033 (3)Diarrhea + febrile neutropenia (1)
Stomatitis + febrile neutropenia (1)
50 mg/m2 (Q3 wks)825332N/Ab2 (2)cFebrile neutropenia (2)
  • a In parentheses, number of courses where day 15 dosing was omitted because of neutropenia.

  • b N/A, not applicable.

  • c Day 8 dosing omitted because of neutropenia.